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B5150 Sigma-Aldrich

Bacitracin zinc salt

from Bacillus licheniformis, ~70,000 U/g

Synonym: Zinc bacitracin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
biological source   Bacillus licheniformis
InChI Key   NKULICGUDKGGRL-FCHFGNCGSA-L
form   powder
mp   250 °C (dec.) (lit.)
solubility   1 M HCl: 50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Application

Bacitracin zinc salt is a peptide antibiotic used to study dysruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is used to study the biosynthesis of sterols and squalene.

Biochem/physiol Actions

Bacitracin is a protease inhibitor. Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

General description

Chemical structure: peptide

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

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Peer-Reviewed Papers
15

References

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