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B5683 Sigma-Aldrich

Betaxolol hydrochloride

>98% (HPLC)

Synonym: SL 75212

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Alcon, Antagonists- Adrenergics, Approved Therapeutics/Drug Candidates,
Quality Level   100
assay   >98% (HPLC)
form   solid
color   white
solubility   H2O: soluble 36 mg/mL
originator   Alcon
SMILES string   Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
InChI   1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H
InChI key   CHDPSNLJFOQTRK-UHFFFAOYSA-N
Gene Information   human ... ADRB1(153)

Description

Application

Betaxolol hydrochloride has been used as a β1 blocking agent:
• for the preparation of crystals of (R,S)-betaxolol (BE-IV).
• to treat mammalian cells prior cell stimulation experiments.
• to study the solid structure of metoprolol.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UA9823000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Peer-Reviewed Papers
15

References

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