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B5936 Sigma

Brefeldin A

from Penicillium brefeldianum, Ready Made Solution, 10 mg/mL in DMSO, 0.2 μm filtered

Synonym: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin

  • CAS Number 20350-15-6

  • Empirical Formula (Hill Notation) C16H24O4

  • Molecular Weight 280.36

  •  Beilstein Registry Number 25191

  •  MDL number MFCD12913297

  •  PubChem Substance ID 329773270

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Properties

Related Categories Antibiotic Ready Made Solutions, Antibiotics, Apoptosis Inducers, Apoptosis and Cell Cycle, Biochemicals and Reagents,
biological source   Penicillium brefeldianum
vapor pressure   0.56 hPa ( 20 °C)
InChI Key   KQNZDYYTLMIZCT-KQPMLPITSA-N
sterility   0.2 μm filtered
form   solution
autoignition temp.   301 °C
concentration   10 mg/mL in DMSO
solubility   DMSO: 10 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   neoplastics
shipped in   wet ice
storage temp.   2-8°C

Description

Application

Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties.

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Hygroscopic.Storage class (TRGS 510): Combustible liquids

Safety & Documentation

Safety Information

RIDADR 
UN 1993 / PGIII
WGK Germany 
2
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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