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B6542 Sigma-Aldrich

Brefeldin A

≥99% (HPLC and TLC), BioXtra, for molecular biology

Synonym: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin

  • CAS Number 20350-15-6

  • Empirical Formula (Hill Notation) C16H24O4

  • Molecular Weight 280.36

  •  Beilstein/REAXYS Number 25191

  •  MDL number MFCD12913297

  •  PubChem Substance ID 24891917

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Application,
Quality Level   PREMIUM
biological source   Penicillium brefeldianum
grade   for molecular biology
InChI Key   KQNZDYYTLMIZCT-KQPMLPITSA-N
product line   BioXtra
assay   ≥99% (HPLC and TLC)
form   powder
solubility   DMSO: 10 mg/mL (Store stock solutions at -20 °C)
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   neoplastics
storage temp.   2-8°C

Description

General description

Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.

Chemical structure: macrolide

Application

Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Principle

Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
GY8410000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Brefeldin A from Penicillium brefeldianum

CAS RN 20350-15-6 Sysnonyms: Decumbin; Ascotoxin; Cyanein; BFA; g,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4 cyclopentanecrotonic acid l-lactone Molecular formula: C16H24O4 Molecular weight: 280.36
Keywords: Absorption, Addition reactions, Cell culture, Centrifugation, Enzyme-linked immunosorbent assay, Ligands, Metabolites

Peer-Reviewed Papers
15

References

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