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B7283 Sigma-Aldrich

Benserazide hydrochloride

≥98% (TLC), solid

Synonym: DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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Properties

Related Categories A to C, Approved Therapeutics/Drug Candidates, Aromatic amino acid decarboxylase, peripheral L-, B, Bioactive Small Molecule Alphabetical Index,
Quality Level   100
biological source   synthetic
assay   ≥98% (TLC)
form   solid
solubility   H2O: 10 mg/mL
originator   Roche
storage temp.   room temp
SMILES string   Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O
InChI   1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
InChI key   ULFCBIUXQQYDEI-UHFFFAOYSA-N
Gene Information   human ... DDC(1644)

Description

General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:
• to inhibit dopa-decarboxylase
• to induce dyskinesia
• to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
• as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
RTECS 
VT9632300
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers
15

References

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