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B7563 Sigma-Aldrich

BRD7389

≥98% (HPLC)

Synonym: 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione

  • CAS Number 376382-11-5

  • Empirical Formula (Hill Notation) C24H18N2O2

  • Molecular Weight 366.41

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   orange
solubility   DMSO: >20 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.

Features and Benefits

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

MAPKAPs

Several protein kinases are activated by the MAPK family members p38α (SAPK2a) and ERKs 1 and 2. The MAPKAP kinases can be subdivided into two groups; those comprising two kinase domains in a single ...
Keywords: Catalysis, Growth factors, Inflammation, Phosphorylations, Polymerization reactions, Transcription

Peer-Reviewed Papers
15

References

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