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B8271 Sigma-Aldrich

Bromoacetic acid N-hydroxysuccinimide ester

≥95%, powder

  • CAS Number 42014-51-7

  • Empirical Formula (Hill Notation) C6H6BrNO4

  • Molecular Weight 236.02

  •  MDL number MFCD00058571

  •  PubChem Substance ID 24892067

  •  NACRES NC.07

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Properties

Related Categories Amine to Sulfhydryl, Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking,
assay   ≥95%
form   powder
reaction suitability   reagent type: cross-linking reagent
solubility   acetone: 25 mg/mL
  DMF: soluble
shipped in   dry ice
storage temp.   −20°C
SMILES string   BrCC(=O)ON1C(=O)CCC1=O
InChI   1S/C6H6BrNO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
InChI key   NKUZQMZWTZAPSN-UHFFFAOYSA-N

Description

Packaging

1 g in poly bottle

100, 250 mg in poly bottle

Application

A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.

Caution

The bromoacetyl group is light sensitive.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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