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B8299 Sigma-Aldrich

N-Butyldeoxynojirimycin

film (dried in situ)

Synonym: Miglustat, NB-DNJ

  • CAS Number 72599-27-0

  • Empirical Formula (Hill Notation) C10H21NO4

  • Molecular Weight 219.28

  •  MDL number MFCD00272581

  •  PubChem Substance ID 24892070

  •  NACRES NA.32

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Properties

Related Categories Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
Quality Level   200
assay   ≥98% (TLC)
form   film (dried in situ)
solubility   water: 9.80-10.20 mg/mL, clear, colorless
storage temp.   2-8°C
SMILES string   CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI   1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
InChI key   UQRORFVVSGFNRO-UTINFBMNSA-N
Gene Information   human ... UGCG(7357)

Description

General description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Application

N-Butyldeoxynojirimycin has been used:
• in the inhibition of glycolipid synthesis in neuroblastoma cells
• in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
• in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

α-glucosidase Inhibitor

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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