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B8562 Sigma-Aldrich

BD 1047 dihydrobromide

≥95% (HPLC)

Synonym: BD 1047 dihydrobromide

  • CAS Number 138356-21-5

  • Empirical Formula (Hill Notation) C13H20Cl2N2 · 2 HBr

  • Molecular Weight 437.04

  •  MDL number MFCD00792739

  •  PubChem Substance ID 329773309

  •  NACRES NA.77

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
color   white
solubility   H2O: >5 mg/mL
storage temp.   2-8°C
SMILES string   Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1
InChI   1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H
InChI key   WOALTFHGLDVJHK-UHFFFAOYSA-N

Description

Application

BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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