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B8685 Sigma-Aldrich

BM 15766 sulfate

≥98% (HPLC), powder

Synonym: 4-[2-[4-[3-(4-Chlorophenyl)-2-propenyl]-1-piperazinyl]ethyl]benzoic acid sulfate

  • CAS Number 86621-94-5

  • Empirical Formula (Hill Notation) C22H25ClN2O2 · H2SO4

  • Molecular Weight 482.98

  •  MDL number MFCD07370131

  •  PubChem Substance ID 24892089

  •  NACRES NA.77

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Properties

Related Categories 7-Dehydrocholesterol reductase, Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white
mp   >300 °C
solubility   DMSO: soluble 4 mg/mL
  water: insoluble
originator   Roche
storage temp.   2-8°C
SMILES string   OS(O)(=O)=O.OC(=O)c1ccc(CCN2CCN(CC2)CC=Cc3ccc(Cl)cc3)cc1
InChI   1S/C22H25ClN2O2.H2O4S/c23-21-9-5-18(6-10-21)2-1-12-24-14-16-25(17-15-24)13-11-19-3-7-20(8-4-19)22(26)27;1-5(2,3)4/h1-10H,11-17H2,(H,26,27);(H2,1,2,3,4)
InChI key   OVMQIVIYKXXEIT-UHFFFAOYSA-N

Description

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

Dehydrocholesterol reductase inhibitor. Inhibits 7-dehydrocholesterol reductase, which catalyzes the last step of cholesterol synthesis.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Cholesterol Biosynthesis Regulation

The amount of cholesterol that is synthesized in the liver is tightly regulated by dietary cholesterol levels. When dietary intake of cholesterol is high, synthesis is decreased and when dietary inta...
BioFiles 2007, 2.7, 6.
Keywords: Gene expression, Transcription

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

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