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B8810 Sigma-Aldrich

BAY 41-2272

≥97% (HPLC)

Synonym: 3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine

  • Empirical Formula (Hill Notation) C20H17FN6

  • Molecular Weight 360.39

  •  MDL number MFCD06411391

  •  PubChem Substance ID 24892096

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, B, Bayer, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
assay   ≥97% (HPLC)
form   powder
color   white to light brown
mp   210.5-211.4 °C
solubility   DMSO: 5 mg/mL, clear (warmed)
originator   Bayer
storage temp.   2-8°C
SMILES string   Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35
InChI   1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChI key   ATOAHNRJAXSBOR-UHFFFAOYSA-N

Description

Application

BAY 41-2272 has been used for the stimulation of guanylate cyclase in heart and neurons.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BAY 41-2272 is an activator of soluble guanylate cyclase at a novel, NO-independent regulatory site. BAY 41-2272 is the first product that stimulates sGC through a non-NO mechanism. BAY 41-2272 inhibits platelet aggregation and induces vasorelaxation without nitrate tolerance.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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