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B9031 Sigma-Aldrich

(−)-Bilobalide from Ginkgo biloba leaves

≥93% (HPLC)

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Properties

Related Categories Cell Biology, Ginkgo biloba, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb),
biological source   plant leaves (Ginkgo biloba)
assay   ≥93% (HPLC)
form   powder
application(s)   HPLC: suitable
color   white
storage temp.   −20°C
SMILES string   CC(C)(C)[C@]1(O)CC2OC(=O)C[C@@]23C(=O)OC4OC(=O)[C@H](O)[C@]134
InChI   1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
InChI key   MOLPUWBMSBJXER-YDGSQGCISA-N

Description

General description

Bilobalide is a biologically active terpenic trilactone (terpenoid) extracted from Ginkgo biloba. It is synthesized from geranylgeranyl pyrophosphate (GGPP).

Application

(-)-Bilobalide from Ginkgo biloba leaves has been used as a reference substance to study the antimicrobial activity of different fractions of G.biloba leaves against a number of Gram-positive and negative bacteria and yeasts.

Packaging

10 mg in glass insert

25, 100 mg in poly bottle

Biochem/physiol Actions

Bilobalide is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. It exhibits neuroprotective, anti-inflammatory, anti-oxidative and anti-apoptotic properties. Bilobalide, a γ-aminobutyric acid (GABA) AA-rho, 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonist, may be used to study the function of these receptors in the brain processes such as cognition and memory. It serves as a specific platelet-activating factor receptor antagonist, which helps in the treatment of cardiovascular (Alzheimer′s disease) and cerebrovascular diseases.

Bioactive terpenoid found in Ginkgo biloba.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Related Content

Ginkgo (Ginkgo biloba) | Plant Profiler

From our library of Related Content, Sigma-Aldrich presents Ginkgo (Ginkgo biloba) | Plant Profiler
Keywords: AGE, Absorption, Alzheimer Disease, Anti-inflammatory agents, Clinical, Coagulation, Degradations, Diabetes, Dialysis, Eliminations, Endocrinology, Gene expression, High performance liquid chromatography, Hormones, Inflammation, Metabolism, Metabolites, Neurotransmitters, PAGE, Pharmaceutical, Positron Emission Tomography, Reversed-phase chromatography

Peer-Reviewed Papers
15

References

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