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BM0001 Sigma-Aldrich

BMS-341400 methanesulfonate

≥98% (HPLC)

Synonym: 1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3H-pyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-N-methyl-H-imidazole-4-carboxamide methanesulfonate (1:1), 1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3Hpyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-4-methylimidazolecarboxamide methanesulfonate

  • CAS Number 296250-54-9

  • Empirical Formula (Hill Notation) C23H22ClN9O2 · CH4O3S

  • Molecular Weight 588.04

  •  PubChem Substance ID 329774349

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   room temp
SMILES string   O=S(C)(O)=O.ClC1=CC(CNC2=C(C(C=NN3CC)=C3N=C4)C4=C(N5C=NC(C(NC)=O)=C5)N=N2)=CC=C1OC
InChI   1S/C23H22ClN9O2.CH4O3S/c1-4-33-21-15(10-29-33)19-14(9-27-21)22(32-11-17(28-12-32)23(34)25-2)31-30-20(19)26-8-13-5-6-18(35-3)16(24)7-13;1-5(2,3)4/h5-7,9-12H,4,8H2,1-3H3,(H,25,34)(H,26,30);1H3,(H,2,3,4)
InChI key   NTAGDQYHYAUFMS-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BMS-341400 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor. BMS-341400 has an IC50 value of 0.3 nM and is 150-fold selective for PDE5 over PDE6 and over 10,000-fold selective for PDE5 over PDE1, PDE2, PDE3, and PDE4.

Features and Benefits

BMS-341400 is available through a partnership between Sigma Life Science and Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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