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C0563 Sigma-Aldrich

Cardiolipin sodium salt from bovine heart

≥97% (TLC), lyophilized powder

Synonym: Diphosphatidylglycerol

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Description

General description

Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. Cardiolipin is an important component of ATP synthase enzyme.

Application

Cardiolipin sodium salt from bovine heart has been used:
• as a phospholipid standard in thin layer chromatography for the quantification of total mitochondrial lipids of Neurospora crassa(89)
• as an internal standard in reverse phase high performance liquid chromatography (RP-HPLC) for quantification of bacterial lipid extracts(90)
• as an antigen to evaluate IgM reaction in systemic lupus erythematosus (SLE) patients(91)

Biochem/physiol Actions

Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.

Packaging

packaged under argon

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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