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C0621 Sigma-Aldrich

CI−994

≥98% (HPLC), powder

Synonym: 4-Acetylamino-N-(2′-aminophenyl)benzamide, Acetyldinaline, Tacedinaline

  • CAS Number 112522-64-2

  • Empirical Formula (Hill Notation) C15H15N3O2

  • Molecular Weight 269.30

  •  MDL number MFCD00866266

  •  PubChem Substance ID 329774808

  •  NACRES NA.77

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Description

Application

CI-994 has been used:
• as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects
• as an HDAC inhibitor for screening in SPEL cells
• to study its effects on human myeloid and erythroid progenitors

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CU8702023

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

Histone Modification and Chromatin Remodeling

Gene expression is governed by complex mechanisms including transcription factor binding to DNA and coordinated changes in chromatin structure. The primary protein components of chromatin are the his...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 10–16
Keywords: Acetylations, Amplification, Cancer, Cell culture, Chromatin immunoprecipitation, Cloning, DNA purification, Diseases, Epigenetics, Gene expression, Immunoprecipitation, Indicators, Methylations, Microarray Analysis, Polymerase chain reaction, Polymerase chain reaction - quantitative, Polymorphisms, Purification, Sequencing, Transcription, Whole genome amplification

Peer-Reviewed Papers
15

References

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EPI003 In Situ Histone Deacetylase (HDAC) Activity Fluorometric Assay Kit, 100 assays in 96 well plates
EPI004 Histone Deacetylase 3 (HDAC3) Activity Assay Kit, 100 assays in 96 well plates
EPI005 Histone Deacetylase 3 (HDAC3) Inhibitor Screening Kit, 100 assays in 96 well plates
EPI006 Histone Deacetylase 8 (HDAC8) Activity Assay Kit, 100 assays in 96 well plates
EPI007 Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates
EPI008 Histone Deacetylase (HDAC) Inhibitor Set I, Set includes 6 inhibitors
EPI009 Histone Deacetylase (HDAC) Inhibitor Set II, Set includes 7 inhibitors

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