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C0742 Sigma-Aldrich

CKI-7 dihydrochloride

≥98% (HPLC), solid

Synonym: N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride

  • CAS Number 1177141-67-1

  • Empirical Formula (Hill Notation) C11H12ClN3O2S · 2HCl

  • Molecular Weight 358.67

  •  MDL number MFCD00897689

  •  PubChem Substance ID 24724430

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Casein Kinase (CK), Cell Biology,
assay   ≥98% (HPLC)
form   solid
storage condition   desiccated
color   white to light tan
solubility   H2O: >5 mg/mL
storage temp.   −20°C
SMILES string   Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
InChI   1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
InChI key   JUAVTXYOCISSSL-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

Caution

Material is hygroscopic

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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