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C1366 Sigma-Aldrich

Anti-CXCR3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CXC Chemokine Receptor 3

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology, Antibodies to Chemokine Receptors,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 16 μg/mL
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   P49682
Gene Information   human ... CXCR3(2833)
mouse ... Cxcr3(12766)
rat ... Cxcr3(84475)

Description

General description

Chemokines bind to specific G protein-coupled cell surface receptors on target cells. Five CXC receptors (CXCR1-5), nine CC receptors (CCR1-9) and one CXXXC receptor (CX3CR1) have been cloned to date. Expression of chemokine receptors can be restricted to some cell types (CXCR1 is expressed in neutrophils) while others (such as CCR2) are expressed in a wide variety of cells. CXCR-3, also known as the IP-10/Mig receptor, shares approximately 40% protein sequence idENTITY_TYPE_CODE with CXCR-1 and CXCR-2, and 34.2-36.9% amino acid sequence idENTITY_TYPE_CODE with the five known CC chemokine receptors 1-5. CXCR-3 is highly expressed by IL-2-activated T lymphocytes (Th1), but not by resting T lymphocytes, B lymphocytes, monocytes or granulocytes. CXCR-3 binds IP-10 and Mig (but not PF4) with high affinity and mediates Ca2+ mobilization and chemotaxis. CXCR-3 does not bind any of the CXC chemokines containing the ELR motif. CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseases including atheroslerosis, Alzheimer′s, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.

Rabbit polyclonal anti-CXCR3 antibody specifically recognizes human CXC Chemokine Receptor 3 by immunohistochemistry with formalin-fixed, paraffin embedded tissues. Not tested for other uses. The immunizing peptide has 82% homology with the rat and mouse gene. Other species reactivity has not been confirmed.

Immunogen

synthetic peptide corresponding to the C-terminus of human CXC chemokine receptor 3 (CXCR3), conjugated to KLH. The immunizing peptide has 82% homology with the rat and mouse gene.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Rabbit polyclonal anti-CXCR3 antibody is used to tag CXC Chemokine Receptor 3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of CXC Chemokine Receptor 3 in processes such as the mediation of Ca2+ mobilization and chemotaxis.

Physical form

Solution in phosphate buffered saline containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
15

References

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