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C1493 Sigma-Aldrich

Cilnidipine

≥98% (HPLC), powder

Synonym: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester, FRC 8653

  • CAS Number 132203-70-4

  • Empirical Formula (Hill Notation) C27H28N2O7

  • Molecular Weight 492.52

  •  MDL number MFCD00865853

  •  PubChem Substance ID 24892414

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Calcium Channel Modulators, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   light yellow
solubility   H2O: ≤2 mg/mL
  DMSO: ≥20 mg/mL
SMILES string   COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC\C=C\c3ccccc3
InChI   1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
InChI key   KJEBULYHNRNJTE-DHZHZOJOSA-N

Description

Application

Cilnidipine has been used:
• in cell viability assay of pheochromocytoma (nPC12) cells
• in photoirradiation and photodegradation studies
• to understand effect on albuminuria in diabetic nephropathy

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Protect from high temperatures.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
US7975550
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Calcium Channels

The voltage-gated calcium channels constitute one group of a superfamily of ion channels that also includes sodium and potassium channels and amongst which exists functional, sequence and topological...
Keywords: Cardiovascular, Clinical, Diabetes, Gene expression, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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