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C1494 Sigma-Aldrich

Carmofur

≥98% (HPLC), powder

Synonym: 1-Hexylcarbamoyl-5-fluorouracil, HCFU

  • CAS Number 61422-45-5

  • Empirical Formula (Hill Notation) C11H16FN3O3

  • Molecular Weight 257.26

  •  MDL number MFCD00866284

  •  PubChem Substance ID 329774890

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology,
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >15 mg/mL
storage temp.   2-8°C
SMILES string   CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
InChI   1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChI key   AOCCBINRVIKJHY-UHFFFAOYSA-N

Description

Application

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (Mpro) in vitro.

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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