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C1867 Sigma-Aldrich

Carrageenan

Non-gelling, Mixture of κ and λ carrageenans

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Polysaccharide More...
quality   Non-gelling

Description

General description

Carrageenans are mucopolysaccharides from the cell walls of the red algae. They are anionic linear polymers composed of 1,3α-1,4β-galactans having one (κ-), two (ι-) or three (λ-) sulfates per disaccharide unit. In ionic solutions, κ- and ι-carrageenans self-associate into helical structures that form rigid or flexible gels, respectively. λ-carrageenans do not form helices and are non-gelling. Carrageenans are used commercially as thickeners and stabilizing agents.

Application

Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages. As ι-, κ-, and λ-carrageenans have varying degress of sulfation, they may be studied comparatively for differences in protective, antiviral, and immunosuppression activities.

Non-gelling carrageenan is used to induce inflammation and inflammatory pain in the rodent hindpaw or air pouch models. More recently carrageenan has been injected directly into the joints of rodents to model arthritic pain and inflammation.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
FI0700000

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway
Protocols & Articles
Peer-Reviewed Papers
15

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C1013 Carrageenan, suitable for gel preparation

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