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C1879 Sigma-Aldrich

Choline chloride

≥98%

Synonym: (2-Hydroxyethyl)trimethylammonium chloride

  • CAS Number 67-48-1

  • Linear Formula (CH3)3N(Cl)CH2CH2OH

  • Molecular Weight 139.62

  •  Beilstein/REAXYS Number 3563126

  •  EC Number 200-655-4

  •  MDL number MFCD00011721

  •  PubChem Substance ID 57653990

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
biological source   synthetic
InChI Key   SGMZJAMFUVOLNK-UHFFFAOYSA-M
assay   ≥98%
form   powder or crystals
application(s)   cell culture | mammalian: suitable
color   colorless to white
mp   302-305 °C (dec.) (lit.)

Description

General description

Choline chloride is the synthetic form of vitamin B4, choline and is a common poultry feed.

Application

Choline chloride has been used:
• as a substrate for measuring choline oxidase enzyme activity using fluorescence measurements
• as a component of non-physiological buffers for testing calcium based inhibition of cytochrome c oxidaseP
• as a component of perfusate solution for studying arterial pressure in jejunum samples

Packaging

1, 5 kg in poly drum

500 g in poly bottle

Biochem/physiol Actions

Choline chloride treatment of radish seeds modulates phosphatidylcholine and phosphatidylethanolamine levels. It elicits hepatoprotective effects and modulates methyl carbon based metabolic pathways.

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
KH2975000

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway
Protocols & Articles
Peer-Reviewed Papers
15

References

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