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C2037 Sigma-Aldrich

Cytochrome c from bovine heart

≥95% based on Mol. Wt. 12,327 basis

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Cytochrome c, Cytochromes,
Quality Level   300
biological source   bovine heart
assay   ≥95% based on Mol. Wt. 12,327 basis
form   powder or crystals
mol wt   12327 Da
application(s)   cell analysis: suitable
storage temp.   −20°C
Gene Information   cow ... CYC1(512500)

Description

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Packaging

1, 5 g in glass bottle

50, 100, 500 mg in glass bottle

Biochem/physiol Actions

The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen.

Preparation Note

Prepared using TCA.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
HA5365000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis Proteins on Proteomix® SCX-NP1.7, Demonstration of Column Stability with Repeated Injections

From our library of Articles, Sigma-Aldrich presents HPLC Analysis Proteins on Proteomix® SCX-NP1.7, Demonstration of Column Stability with Repeated Injections
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Cytochrome c Species Variants on Discovery® BIO PolyMA-SCX (Ion Exchange)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cytochrome c Species Variants on Discovery® BIO PolyMA-SCX (Ion Exchange)
Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Cytochrome c Species Variants on Discovery® BIO Wide Pore C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cytochrome c Species Variants on Discovery® BIO Wide Pore C18
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Peptides and Proteins on Proteomix® SCX-NP1.7, 3 cm x 4.6 mm I.D. Column

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Peptides and Proteins on Proteomix® SCX-NP1.7, 3 cm x 4.6 mm I.D. Column
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins Comparing Ion Selectivity on Proteomix® SCX-NP5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins Comparing Ion Selectivity on Proteomix® SCX-NP5
Keywords: Chromatography, High performance liquid chromatography, Ion Exchange

HPLC Analysis of Proteins Comparing Ion Selectivity on Proteomix® WCX-NP5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins Comparing Ion Selectivity on Proteomix® WCX-NP5
Keywords: Chromatography, High performance liquid chromatography, Ion Exchange

HPLC Analysis of Proteins and Peptides on Proteomix® WCX, Comparison of Different Particle Sizes

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins and Peptides on Proteomix® WCX, Comparison of Different Particle Sizes
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins and Peptides on Proteomix® WCX-NP1.7 Demonstrating Lot-to-Lot Reproducibility

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins and Peptides on Proteomix® WCX-NP1.7 Demonstrating Lot-to-Lot Reproducibility
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins by Cation Exchange on Proteomix® WCX-NP5: Affect of pH

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins by Cation Exchange on Proteomix® WCX-NP5: Affect of pH
Keywords: Chromatography, High performance liquid chromatography, Ion Exchange

HPLC Analysis of Proteins by Cation Exchange on Proteomix® WCX: Affect of Particle Size

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins by Cation Exchange on Proteomix® WCX: Affect of Particle Size
Keywords: Chromatography, High performance liquid chromatography, Ion Exchange

HPLC Analysis of Proteins on BIOshell™ A160 Peptide C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on BIOshell™ A160 Peptide C18
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins on Discovery® BIO PolyMA-SCX (Analyte Set #2)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on Discovery® BIO PolyMA-SCX (Analyte Set #2)
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins on Proteomix® SCX Columns, Effect of Particle Size of Resolution

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on Proteomix® SCX Columns, Effect of Particle Size of Resolution
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins on Proteomix® SCX-NP1.7, Demonstration of Lot-to-Lot Reproducibility

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on Proteomix® SCX-NP1.7, Demonstration of Lot-to-Lot Reproducibility
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Proteins on Proteomix® SCX-NP5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on Proteomix® SCX-NP5
Keywords: High performance liquid chromatography, Separation

HPLC Analysis of Proteins on Proteomix® WCX-NP5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on Proteomix® WCX-NP5
Keywords: High performance liquid chromatography, Proteomics

HPLC Analysis of Proteins on TSKgel® BioAssist S, Ion Selectivity Comparison

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on TSKgel® BioAssist S, Ion Selectivity Comparison
Keywords: Chromatography, High performance liquid chromatography, Ion Exchange

HPLC Analysis of Proteins on TSKgel® BioAssist S

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on TSKgel® BioAssist S
Keywords: High performance liquid chromatography, Proteomics

HPLC Analysis of Proteins with Different pI Values on Proteomix® SCX-NP3

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins with Different pI Values on Proteomix® SCX-NP3
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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