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C213050 Sigma-Aldrich

DMT-2′O-TBDMS-rC(ac) Phosphoramidite

configured for (ÄKTA® and OligoPilot®)

Synonym: N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-cytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

  • CAS Number 121058-88-6

  • Empirical Formula (Hill Notation) C47H64N5O9PSi

  • Molecular Weight 902.10

  •  MDL number MFCD09842111

  •  PubChem Substance ID 329774951

  •  NACRES NA.51

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Properties

Related Categories Chemical Synthesis, DMT-2′O-TBDMS-rC(ac) Phosphoramidite, Phosphoramidites and Reagents for Oligonucleotide Synthesis (Proligo Reagents), RNA Phosphoramidites, Standard Deprotected 2′O-TBDMS RNA Phosphoramidites More...
Quality Level   200
biological source   non-animal source (no BSE/TSE risk)
product line   Proligo Reagents
assay   ≥99% (31P-NMR)
  ≥99.0% (reversed phase HPLC)
  conforms (1H-NMR)
  conforms (LC/MS)
form   powder
application(s)   oligo synthesis: suitable
impurities   ≤0.3% water content (Karl Fischer)
  ≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
  ≤0.5% single Impurity (reversed phase HPLC)
  ≤3% residual Solvent content
color   white to off-white
λ   conforms (UV/VIS Identity)
compatibility   configured for (ÄKTA® and OligoPilot®)
nucleoside profile   base: cytidine
base protecting group: acetyl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: fast/standard
storage temp.   −20°C
SMILES string   COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5
InChI   1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1
InChI key   QKWKXYVKGFKODW-YOEDQOPESA-N

Description

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

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