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C247 Sigma-Aldrich

Cyclazosin hydrochloride

solid

Synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) decahydroquinoxaline

  • CAS Number 146929-33-1

  • Empirical Formula (Hill Notation) C23H27N5O4 · HCl

  • Molecular Weight 473.95

  •  MDL number MFCD01860867

  •  PubChem Substance ID 24892491

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists- Adrenergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
form   solid
color   white
solubility   H2O: 1.8 mg/mL
  methanol: 14 mg/mL
  DMSO: 2.5 mg/mL
storage temp.   room temp
SMILES string   Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(C4CCCCC34)C(=O)c5ccco5
InChI   1S/C23H27N5O4.ClH/c1-30-19-12-14-15(13-20(19)31-2)25-23(26-21(14)24)28-10-9-27(16-6-3-4-7-17(16)28)22(29)18-8-5-11-32-18;/h5,8,11-13,16-17H,3-4,6-7,9-10H2,1-2H3,(H2,24,25,26);1H
InChI key   SKDIDWRQDBIQBS-UHFFFAOYSA-N

Description

Packaging

25 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

α1B-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Alpha 1 Adrenoceptor Modulators

α1-Adrenoceptors are widely distributed, and are activated either by norepinephrine released from sympathetic nerve terminals or by epinephrine released from the adrenal medulla. Receptor activation ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Gene expression, Gluconeogenesis, Transduction

Peer-Reviewed Papers
15

References

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