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C271 Sigma-Aldrich

CX546

≥98% (HPLC), solid

Synonym: 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine

  • CAS Number 215923-54-9

  • Empirical Formula (Hill Notation) C14H17NO3

  • Molecular Weight 247.29

  •  MDL number MFCD01860868

  •  PubChem Substance ID 24277960

  •  NACRES NA.77

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Properties

Related Categories AMPA/Kainate Other, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   white to off-white
solubility   DMSO: ≥10 mg/mL
storage temp.   2-8°C
SMILES string   O=C(N1CCCCC1)c2ccc3OCCOc3c2
InChI   1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
InChI key   LJUNPHMOGNFFOS-UHFFFAOYSA-N
Gene Information   human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Description

General description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Application

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Positive AMPA glutamate receptor modulator.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Caution

Photosensitive

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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