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C3025 Sigma-Aldrich

(±)-Chlorpheniramine maleate salt

≥99% (perchloric acid titration)

  • CAS Number 113-92-8

  • Empirical Formula (Hill Notation) C16H19ClN2 · C4H4O4

  • Molecular Weight 390.86

  •  EC Number 204-037-5

  •  MDL number MFCD00069225

  •  PubChem Substance ID 24277767

  •  NACRES NA.77

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Properties

Related Categories Antagonists- Histaminergics, Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
assay   ≥99% (perchloric acid titration)
mp   130-135 °C (lit.)
originator   Bayer
SMILES string   CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI   1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key   DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information   human ... HRH1(3269)

Description

General description

Chlorpheniramine maleate (CPM)/(3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine is an alkylamine antihistamine.

Application

(±)-Chlorpheniramine maleate salt has been used:
• as H1 receptor antagonist to determine the receptor function
• to block the effect of compound 48/80 on plasma IGF-I
• as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Packaging

5, 25, 100 g in glass bottle

Biochem/physiol Actions

Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.

H1 Histamine receptor antagonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
US6504000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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