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C3130 Sigma-Aldrich

Cortisone 21-acetate

≥99%

Synonym: 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate

  • CAS Number 50-04-4

  • Empirical Formula (Hill Notation) C23H30O6

  • Molecular Weight 402.48

  •  Beilstein/REAXYS Number 2067543

  •  EC Number 200-006-5

  •  MDL number MFCD00003609

  •  PubChem Substance ID 24278306

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
biological source   synthetic (organic)
assay   ≥99%
form   powder
mp   237-240 °C (lit.)
solubility   chloroform: 50 mg/mL, clear, colorless to faintly yellow
shipped in   ambient
storage temp.   room temp
SMILES string   [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O
InChI   1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
InChI key   ITRJWOMZKQRYTA-RFZYENFJSA-N
Gene Information   human ... FNTA(2339), NR3C1(2908)

Description

General description

Cortisone 21-acetate is a prodrug, which has glucocorticoid and mineralocorticoid properties. It is used as a therapeutic option for glucocorticoid replacement.

Application

Cortisone 21-acetate has been used to study its effects in metastasis and phagocytic activity.

Packaging

1, 5, 10, 25 g in poly bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
GM9140000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Steroids on Ascentis® C18 (Mobile phase: 60:40)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® C18 (Mobile phase: 60:40)
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® RP-Amide (Mobile phase: 60:40)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® RP-Amide (Mobile phase: 60:40)
Keywords: Chromatography, Clinical, High performance liquid chromatography

UHPLC Analysis of Corticosteroids on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Corticosteroids on Titan™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

Peer-Reviewed Papers
15

References

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