C3662 Sigma-Aldrich

Cyclosporin A

from Tolypocladium inflatum, ≥95% (HPLC), solid

Synonym: Antibiotic S 7481F1, Cyclosporine

  • CAS Number 59865-13-3

  • Empirical Formula (Hill Notation) C62H111N11O12

  • Molecular Weight 1202.61

  •  Beilstein Registry Number 3647785

  •  MDL number MFCD00274558

  •  PubChem Substance ID 24278028



Related Categories Antibiotics, Antibiotics A to Z, Antibiotics by Application, Antibiotics by Mechanism of Action, Antineoplastic and Immunosuppressive Antibiotics,
Quality Level   PREMIUM
biological source   Tolypocladium inflatum
assay   ≥95% (HPLC)
form   solid
color   white
solubility   dichloromethane: 10 mg/mL
  ethanol: 10 mg/mL
  DMSO: 50 mg/mL
  chloroform: 6 mg/mL
  H2O: insoluble
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
originator   Novartis
storage temp.   2-8°C
Gene Information   human ... PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)



5, 10 mg in glass bottle

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Features and Benefits

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This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 

Milli-Q® Water Purification Solutions
Protocols & Articles


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Peer-Reviewed Papers


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