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C3743 Sigma-Aldrich

CI 976

>98% (HPLC), solid

Synonym: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   WAFNZAURAWBNDZ-UHFFFAOYSA-N
assay   >98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
  H2O: insoluble <2 mg/mL
storage temp.   2-8°C

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

Safety & Documentation

Safety Information

Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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