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C4024 Sigma-Aldrich

Carbamazepine

powder

Synonym: 5H-Dibenz[b,f]azepine-5-carboxamide

  • CAS Number 298-46-4

  • Empirical Formula (Hill Notation) C15H12N2O

  • Molecular Weight 236.27

  •  EC Number 206-062-7

  •  MDL number MFCD00005073

  •  eCl@ss 34051404

  •  PubChem Substance ID 57654002

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Benzodiazepines and Anxiolytics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH,
InChI Key   FFGPTBGBLSHEPO-UHFFFAOYSA-N
form   powder
mp   191-192 °C (lit.)
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL
  H2O: insoluble
  ethanol: soluble
  propylene glycol: soluble
originator   Novartis
storage temp.   2-8°C
Gene Information   human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN5A(6331)
rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

Description

Biochem/physiol Actions

Anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.

Packaging

1, 5, 10, 25 g in glass bottle

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
HN8225000

Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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