C4397 Sigma


Synonym: 5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole



Biochem/physiol Actions

Chlorzoxazone is a skeletal muscle relaxant.


25, 100 g in poly bottle

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Biomedical Applications

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Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
Protocols & Articles


Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

HPLC Analysis of Chlorzoxazone on Discovery® HS-PEG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Chlorzoxazone on Discovery® HS-PEG
Keywords: Chromatography, High performance liquid chromatography, Neurotransmitters, Pharmaceutical

Peer-Reviewed Papers


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