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C4520 Sigma-Aldrich

Cephalothin sodium salt

Synonym: 7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt

  • CAS Number 58-71-9

  • Empirical Formula (Hill Notation) C16H15N2NaO6S2

  • Molecular Weight 418.42

  •  Beilstein Registry Number 4120706

  •  EC Number 200-394-6

  •  MDL number MFCD00072025

  •  PubChem Substance ID 24278314

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
InChI Key   VUFGUVLLDPOSBC-XRZFDKQNSA-M
form   crystalline powder
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.

Application

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics, and for immunology studies in relation to antibiotics. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

General description

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XI0388300

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

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Peer-Reviewed Papers
15

References

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