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C4520 Sigma-Aldrich

Cephalothin sodium salt

Synonym: 7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt

  • CAS Number 58-71-9

  • Empirical Formula (Hill Notation) C16H15N2NaO6S2

  • Molecular Weight 418.42

  •  Beilstein/REAXYS Number 4120706

  •  EC Number 200-394-6

  •  MDL number MFCD00072025

  •  PubChem Substance ID 24278314

  •  NACRES NA.85

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
Quality Level   200
form   crystalline powder
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C
SMILES string   [Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O
InChI   1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1
InChI key   VUFGUVLLDPOSBC-XRZFDKQNSA-M

Description

General description

Chemical structure: ß-lactam

Application

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics, and for immunology studies in relation to antibiotics. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
RTECS 
XI0388300
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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The Antibiotic Selection Guide enables researchers to spend more time on their research discoveries and less time seeking established antibiotic information. Link to hundreds of antibiotics for conta...
Keywords: Antibiotics, Cell biology, Cell culture, Genetic, High performance liquid chromatography, Reversed-phase chromatography

Peer-Reviewed Papers
15

References

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