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C4582 Sigma-Aldrich

β-Carotene

Type II, synthetic, ≥95% (HPLC), crystalline

Synonym: β,β-Carotene, Provitamin A

  • CAS Number 7235-40-7

  • Empirical Formula (Hill Notation) C40H56

  • Molecular Weight 536.87

  •  Beilstein/REAXYS Number 1917416

  •  EC Number 230-636-6

  •  MDL number MFCD00001556

  •  PubChem Substance ID 24892702

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants,
biological source   synthetic
InChI Key   OENHQHLEOONYIE-JLTXGRSLSA-N
type   Type II
assay   ≥95% (HPLC)
form   crystalline
impurities   α-carotene, essentially free
color   dark red-purple to red-brown
mp   178-179 °C
solubility   hexane: soluble 100 μg/mL
  DMSO: 30 μg/mL
  H2O: insoluble
storage temp.   −20°C

Description

Application

β-Carotene has been used:
• as standard for quantification of b-carotene using HPLC analysis
• as a standard for the identification and quantification of authentic standards for carotenoid groups
• for standard curve preparation in the measurement of β-carotene production
• for standard curve preparation in nutritive assays

Packaging

5, 10, 25 mg in ampule

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

β-Carotene (pro-vitamin A) is a member of carotenoids. This antioxidant plays a vital role in human physiology. β-Carotene is an abundant carotenoid. It is considered as a precursor of vitamin A, which is a lipid soluble antioxidant with vitamin E properties.

Caution

Purchase minimum quantity required. Discard one month after opening.

Safety & Documentation

Safety Information

Supplemental Hazard Statements 
Risk of explosion if heated under confinement.
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
FI0329500
Flash Point(F) 
217.4 °F
Flash Point(C) 
103 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Vitamins

HPLC Analysis of Carotenes on Ascentis® Express RP-Amide, Methanol Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carotenes on Ascentis® Express RP-Amide, Methanol Mobile Phase
Keywords: Chromatography, High performance liquid chromatography, Ultraviolet-Visible spectroscopy, Vitamins

LC-MS Analysis of Carotene Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents LC-MS Analysis of Carotene Compounds on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Vitamins

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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