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  • C4607 - Anti-Cdk1 (p34cdc2) antibody produced in rabbit

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C4607 Sigma-Aldrich

Anti-Cdk1 (p34cdc2) antibody produced in rabbit

whole antiserum

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Cycle, Antibodies for Kinase/Phosphatase Biology,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunoprecipitation (IP): suitable
  western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates
species reactivity   human (predicted), rat (predicted), mouse
mol wt   antigen 34 kDa
shipped in   dry ice
storage temp.   −20°C
antibody form   whole antiserum
antibody product type   primary antibodies
contains   0.05% sodium azide as preservative
Gene Information   human ... CDC2(983)
mouse ... Cdc2a(12534)
rat ... Cdc2(54237)

Description

General description

The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2.

Immunogen

synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2.

Application

Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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