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C4680 Sigma-Aldrich

α-Cyclodextrin

powder, BioReagent, suitable for cell culture, ≥98%

Synonym: α-Schardinger dextrin, Cyclohexaamylose, Cyclomaltohexaose

  • CAS Number 10016-20-3

  • Empirical Formula (Hill Notation) C36H60O30

  • Molecular Weight 972.84

  •  Beilstein/REAXYS Number 79627

  •  EC Number 233-007-4

  •  MDL number MFCD00078207

  •  PubChem Substance ID 24892712

  •  NACRES NA.77

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Properties

Related Categories Cell Culture, Chelation/Complexation Compounds, Chemical Synthesis, Cyclodextrins, Reagents and Supplements,
Quality Level   200
sterility   non-sterile
product line   BioReagent
assay   ≥98%
form   powder
application(s)   cell culture | mammalian: suitable
mp   >278 °C (dec.) (lit.)
solubility   H2O: 10 mg/mL
shipped in   ambient
storage temp.   room temp
SMILES string   OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]1[C@H](O)[C@H]2O
InChI   1S/C36H60O30/c37-1-7-25-13(43)19(49)31(55-7)62-26-8(2-38)57-33(21(51)15(26)45)64-28-10(4-40)59-35(23(53)17(28)47)66-30-12(6-42)60-36(24(54)18(30)48)65-29-11(5-41)58-34(22(52)16(29)46)63-27-9(3-39)56-32(61-25)20(50)14(27)44/h7-54H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m1/s1
InChI key   HFHDHCJBZVLPGP-RWMJIURBSA-N

Description

General description

α-Cyclodextrin (α-CD) is a cyclic oligosaccharide that consists of six glucopyranose units linked by α-(1,4) bonds. α-CD acts as a soluble dietary fiber and hence it is preferred to be widely used in food industry.

Application

Useful for the solubilization of nonpolar macromolecules such as fatty acids, lipids, and cholesterol for use in cell culture applications. α-Cyclodextrin has been used to solubilize odanacatib, a cathepsin K inhibitor.

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

α-Cyclodextrin is found to form a firm complex with dietary fats. This way it decreases the bioavailability and absorption of fats. It is known to regulate triglyceride and leptin levels in serum. In rat models, α-Cyclodextrin is shown to induce insulin sensitivity and fecal fat excretion. Thus, α-cyclodextrin is considered to be effective for treating obesity and metabolic syndromes.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Cyclodextrins

Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds i...
Vicki Caligur
BioFiles 2008, 3.3, 32.
Keywords: Cell culture, Hormones, Nuclear magnetic resonance spectroscopy, Substitutions, Vitamins

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Peer-Reviewed Papers
15

References

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