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C4859 Sigma

Cycloheximide solution

Ready-Made Solution, microbial, 100 mg/mL in DMSO, 0.2 μm filtered

Synonym: CHX

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Properties

Related Categories Antibiotic Ready Made Solutions, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal,
Quality Level   PREMIUM
biological source   microbial
InChI Key   YPHMISFOHDHNIV-FSZOTQKASA-N
sterility   0.2 μm filtered
form   solution
concentration   100 mg/mL in DMSO
solubility   DMSO: soluble
suitability   suitable for testing specifications (CHO C. growth inhibitor)
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   fungi
  yeast
storage temp.   2-8°C
Gene Information   human ... FKBP1A(2280), PIN1(5300)

Description

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Packaging

1 mL in glass bottle

Specificity

Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.

Protocols & Applications

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Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2810 6.1 / PGII
WGK Germany 
3
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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