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C4870 Sigma-Aldrich

Anti-CMTM2 (52-65) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-CKLFSF2, Anti-Chemokine-like factor superfamily 2

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Properties

Related Categories Alphabetical Index, Antibodies, CI-CN, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:500-1:2,000
species reactivity   human
mol wt   antigen ~27 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
UniProt accession no.   Q8TAZ6
Gene Information   human ... CMTM2(146225)

Description

General description

CMTM2 (CKLF-like MARVEL transmembrane domain-containing protein 2) is a part of the chemokine-like factor superfamily (CKLFSF). Immunohistochemistry shows that CMTM2 is expressed in testis, mainly in spermatogonia and the seminiferous tubular fluid. Further analysis shows the presence of CMTM2 in meiotic and post-meiotic germ cells. The protein localizes to the endoplasmic reticulum.

Immunogen

synthetic peptide corresponding to amino acids 52-65 of human CMTM2.

Application

Anti-CMTM2 (52-65) antibody produced in rabbit is suitable for western blot at a dilution of 1:500-1:2,000.

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

CMTM2 (CKLF-like MARVEL transmembrane domain-containing protein 2) negatively regulates HIV-1 transcription by suppressing AP1 and CREB activity. CMTM2 promoter is hypermethylated in colorectal cancer tissue samples. It shows abnormal expression in infertile patients′ testes.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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