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C4905 Sigma-Aldrich

Galactocerebrosides from bovine brain

≥97% (TLC)

Synonym: Ceramide β-D-galactoside

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Description

General description

A mixture of type I (containing α-hydroxy fatty acid) and type II (containing non-hydroxy fatty acid) cerebrosides. Galactocerebroside (GalCer) is a glycosphingolipid, that consists of a single galactose residue, connected to ceramide . GalCer is present within the exofacial leaflet of the lipid bilayer.

Application

Galactocerebrosides from bovine brain has been used to find the receptor activity of surface-immobilized galactosylceramide. It has also been used in sulfatide binding assay.

Packaging

10, 25 mg in poly bottle

Biochem/physiol Actions

Galactocerebroside (GalCer) participates in the progression and maintenance of myelin. This oligodendroglial lipid is used as an immunohistochemical tool for studying oligodendrocytes.

Galactose linked to ceramide by a β-glycosidic linkage; the major lipid in adult brain, representing approximately 16% of total lipid; they are mainly localized to myelin and are markedly reduced in demyelinating diseases.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Glycosphingolipids

Glycosphingolipids (sometimes called glycolipids) have been found in lower and higher eukaryotic sources. They are composed of a glycan structure attached to a lipid tail that contains the sphingolip...
Glycobiology Analysis Manual, 2nd Edition
Keywords: Acetylations, Acylations, Cancer, Degradations, Gene expression, Growth factors, High performance liquid chromatography, Hydroxylations, Sulfations, Transduction

Peer-Reviewed Papers
15

References

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