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C4982 Sigma-Aldrich

Cytochrome P450 human

3A4 isozyme microsomes, with P450 reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cancer Research, Cancer Research Enzymes, Cell Biology,
Quality Level   200
recombinant   expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
packaging   vial of ~0.5 nmol
  vial of ≥25 units
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CYP3A4(1576)

Description

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.

Other Notes

Microsomes containing recombinant human CYP3A4 and recombinant rabbit NADPH-P450 reductase

Unit Definition

One unit will convert 1 nanomole of testosterone to 6β-hydroxytestosterone per minute at pH 7.4 at 37 °C.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles
Peer-Reviewed Papers
15

References

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