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C4991 Sigma-Aldrich

Cephalomannine

≥97% (HPLC), solid

Synonym: NSC 318735

  • CAS Number 71610-00-9

  • Empirical Formula (Hill Notation) C45H53NO14

  • Molecular Weight 831.90

  •  MDL number MFCD01075131

  •  PubChem Substance ID 24724441

  •  NACRES NA.77

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics by Application, Antibiotics by Mechanism of Action, Antibiotics  A-F,
assay   ≥97% (HPLC)
form   solid
solubility   DMSO: soluble 14 mg/mL
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   neoplastics
storage temp.   room temp
SMILES string   C\C=C(/C)C(=O)N[C@H]([C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)C4[C@@](C)([C@@H](O)C[C@H]5OC[C@@]45OC(C)=O)C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C)c6ccccc6
InChI   1S/C45H53NO14/c1-9-23(2)39(52)46-33(27-16-12-10-13-17-27)34(50)41(54)58-29-21-45(55)38(59-40(53)28-18-14-11-15-19-28)36-43(8,30(49)20-31-44(36,22-56-31)60-26(5)48)37(51)35(57-25(4)47)32(24(29)3)42(45,6)7/h9-19,29-31,33-36,38,49-50,55H,20-22H2,1-8H3,(H,46,52)/b23-9+/t29-,30-,31+,33-,34+,35+,36?,38-,43+,44-,45+/m0/s1
InChI key   DBXFAPJCZABTDR-UJLUYDJNSA-N

Description

General description

Chemical structure: ß-lactam

Application

Cephalomannine has been used for the identification of fungal taxol (anti-cancer drug) in liquid culture.

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

Cephalomannine is isolated from Taxus wallichiana, and serves as an antifungal agent.

Cephalomannine is a taxol derivative with antitumor, antiproliferative properties.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Paclitaxel and Related Compounds on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paclitaxel and Related Compounds on Ascentis® Express F5
Keywords: Antitumor agents, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Taxols on Discovery® HS F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Taxols on Discovery® HS F5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

UHPLC analysis of Taxanes on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC analysis of Taxanes on Titan™ C18
Keywords: Chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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