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C4999 Sigma-Aldrich

Proinsulin C-Peptide (55-89) human

bioactive peptide hormone

Synonym: Proinsulin connecting peptide

  • CAS Number 11097-48-6

  • Empirical Formula (Hill Notation) C153H259N49O52

  • Molecular Weight 3616.99

  •  MDL number MFCD00076294

  •  PubChem Substance ID 329775073

  •  NACRES NA.26

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gastrointestinal Peptides, Insulin Peptides, Peptides and Proteins,
Quality Level   200
InChI Key   JEPNOJXFZHBCTB-ZCUALFGZSA-N
assay   ≥95% (HPLC)
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg

General description

Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-peptide. The product here is the 35-mer peptide (Arg−Arg-C-Peptide-Lys-Arg) observed to separate the insulin A and B chains.

Biochem/physiol Actions

C-Peptide Fragment (55-89) is a fragment derived from the proinsulin C-peptide. C-peptide has cell signaling activity that involves calcium-dependent intracellular signaling. C-Peptide Fragment 55-89 may be used to help researchers understand the role of specific sequences within the C-peptide in binding, conformation and function of C-peptide.

C-Peptide was initially thought to have no intrinsic biological activity. More recent research has identified multiple biological effects of C-peptide, including binding to cell membranes, activation of signaling pathways, and stimulation of Na+,K+-ATPase and endothelial nitric oxide synthetase. However, the exact function of C-peptide is unclear due to conflicting physiological effects.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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