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C5174 Sigma-Aldrich

4′-Chlorodiazepam

≥98% (TLC)

Synonym: 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one, Ro 5-4864, Ro5-4864

  • CAS Number 14439-61-3

  • Empirical Formula (Hill Notation) C16H12Cl2N2O

  • Molecular Weight 319.19

  •  Beilstein/REAXYS Number 685202

  •  MDL number MFCD00043406

  •  PubChem Substance ID 24892765

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Properties

Related Categories Benzodiazepines and Anxiolytics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology,
InChI Key   PUMYFTJOWAJIKF-UHFFFAOYSA-N
assay   ≥98% (TLC)
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
solubility   2-hydroxypropyl-β-cyclodextrin: insoluble
  H2O: insoluble
Gene Information   rat ... Tspo(24230)

Description

Application

4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DF0500000

Documents

Certificate of Analysis

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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