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C5269 Sigma-Aldrich

Clindamycin hydrochloride

lincosamide antibiotic

Synonym: (7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin

  • CAS Number 21462-39-5

  • Empirical Formula (Hill Notation) C18H33ClN2O5S · HCl

  • Molecular Weight 461.44

  •  Beilstein/REAXYS Number 4070786

  •  MDL number MFCD07793327

  •  PubChem Substance ID 24892772

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
InChI Key   AUODDLQVRAJAJM-XJQDNNTCSA-N
form   crystalline
impurities   ≤2 mol/mol EtOH
solubility   H2O: 50 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Other Notes

Antibacterial and antiprotozoal antibiotic of the lincosamide class.

Keep container tightly closed in a dry and well-ventilated place.

Packaging

10 mg in poly bottle

50, 100 mg in glass bottle

Application

Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding.

Biochem/physiol Actions

Clindamycin hydrochloride is highly effective against anaerobic species.

Clindamycin is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. It has antibacterial activity against Gram-positive cocci and antiprotozoal activity against Taxoplasma.

General description

Chemical structure: macrolide

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the antibiotic potency of Clindamycin hydrochloride, Product C5269?
We do not include the potency of the compound in our quality specifications. Please contact Sigma-Aldrich Technical Service for the availability of lot-specific potency from our supplier.
What is the pH of an aqueous solution of Clindamycin hydrochloride, Product C5269?
The expected pH of a 100 mg/ml aqueous solution is from 3.0 to 5.5, per USP 31, p. 1796.
You list the purity of Clindamycin hydrochloride, Product C5269, as determined by thin layer chromatography. Is it possible to determine purity by other chromatographic methods?
The USP 31 describes a liquid chromatographic method utilizing Clindamycin Hydrochloride and Lincomycin Hydrochloride standards. Other publications may be searched on PubMed, such as G. La Follette et al.,J Chromatogr., Vol. 431 (No. 2), pp. 379-388 (1988).
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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References

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