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C5624 Sigma-Aldrich

Cryptotanshinone

≥98% (HPLC)

Synonym: 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione, Cryptotanshinon, Tanshinone c

  • CAS Number 35825-57-1

  • Empirical Formula (Hill Notation) C19H20O3

  • Molecular Weight 296.36

  •  MDL number MFCD07636810

  •  PubChem Substance ID 329775097

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -80 to -99°, c = 0.5 in chloroform-d
storage condition   desiccated
  protect from light
color   orange-brown
solubility   DMSO: ≥5 mg/mL
storage temp.   2-8°C
SMILES string   C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
InChI   1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChI key   GVKKJJOMQCNPGB-JTQLQIEISA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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