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C5740 Sigma-Aldrich

Cytochrome P450 human

2E1 isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cytochrome P450 Human Isozyme Microsomes, Cytochrome P450s (CYPs),
recombinant   expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
description   1.0 nmole P450 2E1 per 0.5 ml vial
form   buffered aqueous solution (100 mM potassium phosphate, pH 7.4)
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CYP2E1(1571)

Description

Application

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Alterations in the renal formation of Cytochrome P450 metabolites from arachidonic acid may participate in the formation of hypertension. Therefore, they have been identified as candidate mediators in the development of this multifactorial disease.

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.

Analysis Note

Cytochrome c Reductase, b5, P450 content and p-Nitrophenol Hydroxylase activity reported on a lot-specific basis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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