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C6240 Sigma-Aldrich

CITCO

≥98% (HPLC), solid

Synonym: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

  • CAS Number 338404-52-7

  • Empirical Formula (Hill Notation) C19H12N3OCl3S

  • Molecular Weight 436.74

  •  MDL number MFCD00139608

  •  PubChem Substance ID 24724448

  •  NACRES NA.77

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Properties

Related Categories Androgen, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
assay   ≥98% (HPLC)
form   solid
storage condition   desiccated
solubility   DMSO: soluble 28 mg/mL
  H2O: insoluble
storage temp.   −20°C
SMILES string   Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
InChI   1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
InChI key   ZQWBOKJVVYNKTL-AUEPDCJTSA-N

Description

General description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Application

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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