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C6506 Sigma-Aldrich

4-Chloro-DL-phenylalanine

Green Alternative

Synonym: PCP, PCPA

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Enzyme Inhibitors, Greener Alternative Products,
InChI Key   NIGWMJHCCYYCSF-UHFFFAOYSA-N
greener alternative product characteristics   Waste Prevention
Designing Safer Chemicals
Reduce Derivatives
Learn more about the Principles of Green Chemistry.
mp   >240 °C (dec.) (lit.)
greener alternative category   Re-engineered
storage temp.   room temp
Gene Information   human ... TPH1(7166), TPH2(121278)

Description

Application

4-Chloro-DL-phenylalanine has been used:
• as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
• to induce insomnia in rat models
• used to treat embryos to examine its effect on serotonin
• for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
• to feed flies to explore serotonin effect

Packaging

5, 25 g in poly bottle

Biochem/physiol Actions

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Tryptophan hydroxylase inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
AY4390010

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

GC Analysis of Basic Drugs on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm) after SPME using 65 μm PDMS/DVB Fiber, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm) after SPME using 65 μm PDMS/DVB Fiber, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification, Solid phase microextractions

HPLC Analysis of p-Chlorophenylalanine Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of p-Chlorophenylalanine Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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