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C6706 Sigma-Aldrich

Z-Leu-Leu-Norvalinal

≥90% (HPLC), powder

Synonym: MG115, Z-LLnV

  • CAS Number 133407-86-0

  • Empirical Formula (Hill Notation) C25H39N3O5

  • Molecular Weight 461.59

  •  PubChem Substance ID 329775129

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Description

Amino Acid Sequence

Z-Leu-Leu-Nva

Packaging

1, 5 mg in serum bottle

Biochem/physiol Actions

Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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