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C6762 Sigma-Aldrich

Cytochalasin B from Drechslera dematioidea

≥98% (HPLC), powder

Synonym: Phomin

  • CAS Number 14930-96-2

  • Empirical Formula (Hill Notation) C29H37NO5

  • Molecular Weight 479.61

  •  Beilstein/REAXYS Number 1096207

  •  EC Number 239-000-2

  •  MDL number MFCD00077704

  •  PubChem Substance ID 24892890

  •  NACRES NA.32

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Properties

Related Categories Actin Inhibitors and Probes, Antibiotics, Antibiotics A to Z, Antibiotics by Application, Antibiotics by Mechanism of Action,
InChI Key   GBOGMAARMMDZGR-TYHYBEHESA-N
Quality Level   300
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: 10 mg/mL
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   fungi
storage temp.   −20°C

Description

Packaging

1, 5, 10, 25, 50 mg in serum bottle

Biochem/physiol Actions

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGI
WGK Germany 
3
RTECS 
RO0205000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
BioFiles v7 n4
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, Phosphorylations, Transcription

Peer-Reviewed Papers
15

References

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