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C6780 Sigma-Aldrich

α-Casein from bovine milk

≥70% αs-casein basis (electrophoresis), lyophilized powder

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Properties

Related Categories Molecular Biology, Phosphorylation Analysis, Post-Translational Modification, Proteomics, Reagents and Controls for Phosphoprotein Analysis More...
Quality Level   200
biological source   bovine milk
assay   ≥70% αs-casein basis (electrophoresis)
form   lyophilized powder
application(s)   mass spectroscopy (MS): suitable
storage temp.   −20°C
Gene Information   cow ... CSN1(282208), CSN1S2(282209)

Description

Application

α-Casein from bovine milk is an Immunoglobulin E (IgE)-binding epitope belonging to the Casein phosphoprotein family. It has been used in studies of children with insulin-dependent diabetes mellitus (IDDM), due to the strong cross-reactivity of α-casein antibodies with insulin. Studies of children displaying (IDDM) show higher levels of α-casein antibodies than control siblings, which may serve as a risk marker for IDDM.

Packaging

1, 5 g in poly bottle

250 mg in poly bottle

Biochem/physiol Actions

α-Casein can be an immunogen in young children, and anti-a-casein antibodies have strong cross-reactivity with insulin. This effect can explain the uncommon insulin autoimmunity, but it does not appear to progress to Type I diabetes.

Preparation Note

Chromatographically purified

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Caseins on BIOshell™ A400 Protein C4

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caseins on BIOshell™ A400 Protein C4
Keywords: Chromatography, High performance liquid chromatography, Reversed-phase chromatography, Separation

Peer-Reviewed Papers
15

References

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